When the Governor of Buenos Aires, Don Juan Manuel de Rosas created Las Flores, the land in close to its totality to belonged to himself and his relatives. The administration of the district was not based in the town, which had not yet been founded, but in Estancia San Agustin in the vicinity of Gorchs. The La Blanca lagoon, today located 2,5kms South from city centre in those days covered part of the current city.
When Rosas lost the battle of Caseros his properties were expropriated and 25 March 1856 Manuel Venancio Paz decides to found the pueblo of Las Flores together with surveyor Adolfo Sourdeaux who defined the city limits. There were already some houses there but progress in building was slow; Just before 1860 a temple, a school and a Police Station were built. The arrival of the Railways gave as usual a great impulse as did the arrival of a Banco de la Provincia de Buenos Aires branch, the re-building of the main plaza, a local newspaper, and electricity. During the 20th Century, two important textile mills gave an industrial profile to the city and this lasted until 1990 with the loss of an important number of jobs. Just as it happened in Pergamino and other cities of the interior of the Province, many small workshops were opened and created the Clothing Industrial Chamber of Buenos Aires.
The University Extension of Las Flores brought tertiary studies to the town in 1996 and opened the door to agreements with several private and public institutions. “Indular Enterprises” bought the bankrupt Gatic in 2005 and opened a textile factory in Las Flores.